25-018: A study for a rare blood cancer (PV)
Currently Recruiting
Up to £3,360
London, United Kingdom
A study in healthy participants investigating an experimental new medicine for treating polycythaemia vera (PV) – a rare blood cancer.
Join our clinical trial
We’re doing this trial to test a new concentration of an experimental new medicine, called divesiran, which is being developed to treat polyeythaemia vera (PV) – a rare type of blood cancer. We hope the new concentration will make treatment easier and more convenient for patients with PV. This trial aims to find out the side effects and blood levels of the new concentration of divesiran in healthy volunteers.
Why participate?
If you take part in this trial you’ll be helping medical research – you’ll help us develop a potential new treatment for PV – a rare blood cancer.
In the UK, about 1,140 people are diagnosed with PV each year. PV affects the bone marrow (where blood cells are made) causing the body to produce too many red blood cells, which can make the blood thicker than normal and affect how well it flows through the body. This can cause a wide range of symptoms, but people with PV often have fatigue, itchy skin, brain fog, and low iron levels. It can also lead to serious health problems, which may be life threatening.
Trial details
Delivery method
You’ll take a single dose of trial medicine by injections under the skin of your abdomen.
Schedule
During the 4 weeks before the trial, you’ll have a screening visit, to see if you’re suitable. You’ll stay on the ward for 5 days and 4 nights in a row. Then you’ll leave the ward. You’ll make 3 outpatient visits, and you’ll have a final follow-up visit about 9 weeks after your dose.
The planned admission dates are:
- 13 Jul 2026
- 15 Jul 2026
- 20 Jul 2026
- 21 Jul 2026
Inclusion criteria:
You must:
- be a healthy man or woman, aged 18 to 65
- have a body weight ≥ 50 kg
- have a body mass index (BMI) between 18 and 40
- if you’re a woman of child-bearing potential, use one of the following methods of contraception:
- Progesterone-only contraceptive implants
- IUD, IUS or ‘coil’
Exclusion criteria
You must not:
- have a sensitivity to or history of using certain medicines called biologics (‘oligonucleotide therapies’ or ‘siRNA therapies’)
- be anaemic or have low iron levels
- have smoked or vaped in the last 3 months – we may test your urine for nicotine at any time during this trial
Are you a match?
Age
18 - 65 years old
Study payment
Up to £3,360
Gender
Male or Female
BMI
BMI 18 - 40 kg/m2
Commitment
4 nights, 4 clinic visits